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KMID : 1039420230570020081
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Journal of Pathology and Translational Medicine
2023 Volume.57 No. 2 p.81 ~ p.87
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Aneurysmal bone cyst: a review
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Nasri Elham
Reith John David
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Abstract
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Aneurysmal bone cyst (ABC) is a benign locally destructive bone neoplasm composed of multi-loculated blood-filled cystic spaces. The most common sites of involvement are the meta-diaphysis of the long bones and posterior elements of the vertebrae. Secondary, ABClike changes can complicate a variety of other benign and malignant primary bone neoplasms, including giant cell tumor, fibrous dysplasia, and osteosarcoma. About two-third of primary ABCs have a rearrangement of the USP6 gene, which is not present in the ABC-like changes that occur secondary to other primary bone tumors (i.e., secondary ABC). Primary ABC of bone carries a variable but generally high rate of local recurrence. This paper provides an overview of the pathophysiology, clinical presentation, radiographic and pathologic findings, treatment, and prognosis of ABC.
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KEYWORD
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Bone cyst, Aneurysmal bone cyst, USP6 gene
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